Cary Grant has to be one of the funniest leading men ever. I'm watching the hilarious Father Goose right now, a wonderful example of this talent. And he's handsome to boot. I say that in a manly fashion as I don't swing that way. He's one of those guys who men want to be and women want to be with. Sean Connery and Harrison Ford would likely be on that list.
Angelina Jolie would likely be a woman in this vein. She was ideal in the Tomb Raider movies. Of course I love all women so it's tough to pick others. Ms. Jolie comes to mind right away because I've recently watched some of her movies. Ginger from Chicken Run is also on this list. See -- I love all women. Add Jamie Lee Curtis to put the list on par with the other.